In her opening monologue, host Chelsea Handler talks about how every successful woman is backed by an efficient personal assistant. Chelsea and her round table panelists Michael Yo, Jamie Lee and Ross Mathews discuss Katy Perry stating that she prayed to God for big boobs, a survey that found that the kinky sex revolution is already over, and a fifteen pound baby being born in California. Regina the Makeup Lady does Kathy Griffin's makeup. And Chelsea chats with guest Timothy Olyphant about his show Justified (2010), his proposal that they run away together when he was last on the show, and supporting the charity omaze.com.