When young wife Elyse falls ill with a rare disease she can't possibly have, Dr. Cameron is very interested in the case - so much so that her interest convinces House to take the case, and the team struggles to save her and appease her very attentive husband, Ed. After Dr. House and Dr. Wilson treat a woman at the clinic with new breast implants, the idea that House's new patient Elyse may have breast cancer is raised as a possible diagnosis. But that diagnosis fails to be the answer when Elyse lapses into a coma after starting treatment. House starts to suspect Elyse has contracted a rare sexually transmitted disease, but when Ed and Elyse are questioned individually, they each deny having an affair. To save their patient's life, the team has to acknowledge that House is right: everybody lies.