In an exclusive gated community in California, a family is plagued by a ceaseless tide of rats entering their home from an unknown source. In Pennsylvania, a single mother is forced to move her family into a tent in the front yard when a bug infestation overruns their home. And in Texas, a terrified young boy is awoken by scratching sounds in his closet. His parents soon discover the source: dozens of opossums are living inside the walls of their apartment, and it's only a matter of time before they break out.