Cal heads up a private agency contracted by the FBI, local police, law firms, corporations, and private individuals when they hit roadblocks in their searches for the truth. Joining him are a variety of experts in the field of behavioral evaluation: Dr. Gillian Foster is a gifted psychologist and Cal's professional partner, a woman whose guidance Cal needs, whether he knows it or not; Will Loker is Cal's lead researcher, and he is so aware of the human tendency to lie that he has decided to uncomplicate matters and practice what he terms "radical honesty": he says everything on his mind at all times. Ria Torres, the newest member of the team, arrives at the truth differently by acting more on instinct and using her natural, less-studied ability to read body language and catch certain clues that Cal's other pledges may miss. Lie To Me probes how people can deceive themselves just as easily as they deceive others, and explores the idea that there is nothing more revealing than when we choose to tell the truth and when we decide to lie.