In Season 3, having defeated General Abbot in the battle at Pubba's Cabin, Gus, Jepperd, Becky, and Wendy embark on a journey to Alaska in search of Gus's mother, Birdie, who has been working to uncover the mysterious origins of the deadly Sick. Along the way, they are joined by Dr. Singh, who may have his own dangerous beliefs about Gus and his role in reversing the virus. Meanwhile, a new threat emerges in the form of Helen Zhang, her daughter Rosie, and the ferocious Wolf Boys, who seek to restart human birth and view Gus as the solution to their plans. As they navigate through perilous terrain, Gus and his group of friends find refuge at the Outpost in Alaska, where they meet a new ensemble of characters including Siana and her hybrid daughter Nuka. With the clock to find answers running out, alliances are tested and destinies intertwine, all leading to a thrilling climax that will determine the fate of humanity and hybrids.