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Former soldier turned hired criminal Frank Martin, now living in Miami, has been hired for his latest assignment. Frank has been hired as a bodyguard to Jack Billings, son of Jefferson Billings, a wealthy US official for the US government drug control organization who is attending a conference with the DEA. When Jack is kidnapped by a international crime boss known as Gianni and his associates including his murderous lover Lola and gets implicated in the kidnapping, Frank with help of trusted friend, French police detective Tarconi, sets out to rescue Jack and takes on Gianni and his henchmen, as Gianni infects Jack with a engineered virus which will infect those who come into contact with Jack, as Gianni plans to infect Jefferson and sabotage the conference.